Tumor-specific cytotoxic T cells are crucial for efficacy of immunomodulatory antibodies in patients with lung cancer

JG Aerts, JP Hegmans - Cancer research, 2013 - AACR
There is growing evidence that activation of the immune system may be an effective
treatment for patients with either small cell lung cancer or non–small cell lung cancer …

FOXP3 expression in tumor cells and implications for cancer progression

T Triulzi, E Tagliabue, A Balsari… - Journal of cellular …, 2013 - Wiley Online Library
FOXP3 is a member of the forkhead/winged‐helix family of transcriptional regulators.
Defects in the FOXP3 gene cause an X‐linked autoimmune/immunodeficiency syndrome in …

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

S Yang, Y Liu, MY Li, CSH Ng, S Yang, S Wang, C Zou… - Molecular cancer, 2017 - Springer
Background The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study
FOXP3 expression and regulation, function and clinical implication in human non-small cell …

Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma

AP Ganesan, M Johansson, B Ruffell… - The Journal of …, 2013 - journals.aai.org
Immune cells comprise a substantial proportion of the tumor mass in human nonsmall cell
lung cancers (NSCLC), but the precise composition and significance of this infiltration are …

[HTML][HTML] Visceral obesity promotes lung cancer progression—toward resolution of the obesity paradox in lung cancer

J Barbi, SK Patnaik, S Pabla, R Zollo… - Journal of Thoracic …, 2021 - Elsevier
Introduction Although obesity is associated with adverse cancer outcomes in general, most
retrospective clinical studies suggest a beneficial effect of obesity in NSCLC. Methods …

[HTML][HTML] Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis

RA Soo, Z Chen, RSY Teng, HL Tan, B Iacopetta… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Prognostic significance of immune cells in non-small cell lung cancer: meta-analysis - PMC
Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

The expression of FOXP3 and its role in human cancers

H Jia, H Qi, Z Gong, S Yang, J Ren, Y Liu, MY Li… - … et Biophysica Acta (BBA …, 2019 - Elsevier
FOXP3 is a transcription factor, which belongs to the family of FOX protein. FOXP3 was
initially discovered in regulatory T cells and supposed to play a significant role in the …

Emerging roles of regulatory T cells in tumour progression and metastasis

EC Halvorsen, SM Mahmoud, KL Bennewith - Cancer and metastasis …, 2014 - Springer
The metastasis of cancer is a complex and life-threatening process that is only partially
understood. Immune suppressive cells are recognized as important contributors to tumour …

High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment

GF Ma, Q Miao, YM Liu, H Gao, JJ Lian… - British journal of …, 2014 - nature.com
Background: Forkhead Box P3 (FoxP3) is thought to be a key transcription factor in
regulatory T cells (Tregs), and recent data indicate that it is expressed in several tumour …

FOXP3 and TLR4 protein expression are correlated in non-small cell lung cancer: implications for tumor progression and escape

H Fu, C Li, W Yang, X Gai, T Jia, Y Lei, Y Li - Acta histochemica, 2013 - Elsevier
NSCLC (non-small cell lung cancer) is the most common type of lung cancer and usually
has poor prognosis. FOXP3 in regulatory T cells (Tregs) and toll-like receptor 4 (TLR4) on …