The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions

J Lund, AW Breum, C Gil, S Falk, F Sass, MS Isidor… - Nature …, 2023 - nature.com
Lactate is a circulating metabolite and a signalling molecule with pleiotropic physiological
effects. Studies suggest that lactate modulates energy balance by lowering food intake …

Stimulation of Non-Shivering Thermogenesis by Bioactive Compounds: A Focus on Gut Microbiota-Mediated Mechanisms

Y Alhamoud, T Abudumijiti, J Wu, L Lu, M Zhao… - Trends in Food Science …, 2024 - Elsevier
Background Non-shivering thermogenesis (NST), an essential mechanism for heat
generation without shivering, primarily involves brown and beige fats. This process …

Physical activity and batokines

GU Ortiz, EC de Freitas - American Journal of Physiology …, 2023 - journals.physiology.org
Brown and beige adipose tissue share similar functionality, being both tissues specialized in
producing heat through nonshivering thermogenesis and also playing endocrine roles …

Standardized Ethanol Extract of Cassia mimosoides var. nomame Makino Ameliorates Obesity via Regulation of Adipogenesis and Lipogenesis in 3T3-L1 Cells and …

SW Heo, KS Chung, YS Yoon, SY Kim, HS Ahn… - Nutrients, 2023 - mdpi.com
Obesity is a major cause of conditions such as type 2 diabetes and non-alcoholic fatty liver
disease, posing a threat to public health worldwide. Here, we analyzed the anti-obesity …

[HTML][HTML] The effects of long-term lactate and high-intensity interval training (HIIT) on brain neuroplasticity of aged mice

Z Lei, S Mozaffaritabar, T Kawamura, A Koike… - Heliyon, 2024 - cell.com
Extensive research has confirmed numerous advantages of exercise for promoting brain
health. More recent studies have proposed the potential benefits of lactate, the by-product of …

Deciphering the Therapeutic Role of Lactate in Combating Disuse-Induced Muscle Atrophy: An NMR-Based Metabolomic Study in Mice

Y Zhou, X Liu, Z Qi, L Yang, C Huang, D Lin - Molecules, 2024 - mdpi.com
Disuse muscle atrophy (DMA) is a significant healthcare challenge characterized by
progressive loss of muscle mass and function resulting from prolonged inactivity. The …

[HTML][HTML] Metabolic Activity in Human Intermuscular Adipose Tissue Directs the Response of Resident PPARγ+ Macrophages to Fatty Acids

X Chen, SL Schubert, A Müller, M Pishnamaz… - Biomedicines, 2024 - mdpi.com
Background/Objectives: Peroxisome proliferator-activated receptor gamma (PPARγ) is a
fatty acid-binding transcription activator of the adipokine chemerin. The key role of PPARγ in …