▪ Abstract The separation of sister chromatids at the metaphase to anaphase transition is
one of the most dramatic of all cellular events and is a crucial aspect of all sexual and …

Oscillations in the activity of cyclin-dependent kinases (CDKs) promote progression through
the eukaryotic cell cycle. This review examines how proteolysis regulates CDK activity—by …

In yeast, anaphase depends on cohesin cleavage. How anaphase is controlled in
vertebrates is unknown because their cohesins dissociate from chromosomes before …

Proteolysis mediated by the anaphase-promoting complex (APC) triggers chromosome
segregation and exit from mitosis, yet its regulation is poorly understood. The conserved …

Cyclin A is particularly interesting among the cyclin family because it can activate two
different cyclin-dependent kinases (CDKs) and functions in both S phase and mitosis. An …

Key events in mitosis such as sister chromatid separation and subsequent inactivation of
cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events …

The adaptive responses of a living cell to internal and external signals are controlled by
networks of proteins whose interactions are so complex that the functional integration of the …

The p16INK4a cyclin-dependent kinase inhibitor is implicated in replicative senescence, the
state of permanent growth arrest provoked by cumulative cell divisions or as a response to …

The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of
several diverse cellular processes. Here, we describe the important components of this …

The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3
ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of …