RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

Leishmaniasis: the act of transmission

TD Serafim, IV Coutinho-Abreu, R Dey, R Kissinger… - Trends in …, 2021 - cell.com
The contribution of vector transmission to pathogen establishment is largely underrated. For
Leishmania, transmission by sand flies is critical to early survival involving an irreproducible …

Leishmania parasites exchange drug-resistance genes through extracellular vesicles

N Douanne, G Dong, A Amin, L Bernardo, M Blanchette… - Cell reports, 2022 - cell.com
Leishmania are eukaryotic parasites that have retained the ability to produce extracellular
vesicles (EVs) through evolution. To date, it has been unclear if different DNA entities could …

Biogenesis of extracellular vesicles in protozoan parasites: The ESCRT complex in the trafficking fast lane?

A Cruz Camacho, D Alfandari, E Kozela… - PLoS …, 2023 - journals.plos.org
Extracellular vesicles (EVs) provide a central mechanism of cell–cell communication. While
EVs are found in most organisms, their pathogenesis-promoting roles in parasites are of …

Extracellular vesicles in trypanosomatids: host cell communication

AC Torrecilhas, RP Soares, S Schenkman… - Frontiers in Cellular …, 2020 - frontiersin.org
Trypanosoma cruzi, Trypanosoma brucei and Leishmania (Trypanosomatidae:
Kinetoplastida) are parasitic protozoan causing Chagas disease, African Trypanosomiasis …

Milk exosomes elicit a potent anti-viral activity against dengue virus

VR Yenuganti, S Afroz, RA Khan, C Bharadwaj… - Journal of …, 2022 - Springer
Background Exosomes are nano-sized vesicles secreted by various cells into the intra and
extracellular space and hence is an integral part of biological fluids including milk. In the last …

A protocol for isolation, purification, characterization, and functional dissection of exosomes

A Rai, H Fang, M Fatmous, B Claridge, QH Poh… - … Profiling: Methods and …, 2021 - Springer
Extracellular vesicles (EVs) are membrane-enclosed vesicles released by cells. They carry
proteins, nucleic acids, and metabolites which can be transferred to a recipient cell, locally …

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition

RVH de Carvalho, DS Lima-Junior… - Nature …, 2019 - nature.com
Leishmania RNA virus (LRV) is an important virulence factor associated with the
development of mucocutaneous Leishmaniasis, a severe form of the disease. LRV-mediated …

Guidelines for the purification and characterization of extracellular vesicles of parasites

C Fernandez‐Becerra, P Xander… - Journal of …, 2023 - Wiley Online Library
Parasites are responsible for the most neglected tropical diseases, affecting over a billion
people worldwide (WHO, 2015) and accounting for billions of cases a year and responsible …

Viruses of protozoan parasites and viral therapy: Is the time now right?

P Barrow, JC Dujardin, N Fasel, AD Greenwood… - Virology journal, 2020 - Springer
Infections caused by protozoan parasites burden the world with huge costs in terms of
human and animal health. Most parasitic diseases caused by protozoans are neglected …