During development, mammalian organisms increase in size until a limit is reached that is
mainly determined by the rate and duration of occurrence of cellular divisions increasing …

A small sub-set of mammalian genes are subject to regulation by genomic imprinting such
that only one parental allele is active in at least some sites of expression. Imprinted genes …

Background miRNAs play important roles in the regulation of gene functions. Maternal
dietary modifications during pregnancy and gestation have long-term effects on the …

Accumulating evidence has suggested that a suboptimal early life environment produces
multigenerational developmental defects. A proposed mechanism is stable inheritance of …

Gestational diabetes is a major public health problem because of its prevalence, its
associated complications during pregnancy, and its increased risk for type 2 diabetes later in …

The effect of insulin-like growth factor II (IGF-II) on tumour development in the mouse
mammary gland was studied. To promote extra IGF-II expression in the mammary gland …

Imprinted genes display parent-of-origin-specific expression with this epigenetic system of
regulation found exclusively in therian mammals. Historically, defined imprinted gene …

Keratinocytes are potentially appealing vehicles for the delivery of secreted gene products
because they can be transferred to human skin by the relatively simple procedure of grafting …

The mono-allelic behaviour and sensitivity to changes in regional epigenetic states renders
imprinted genes adaptable and vulnerable; in all cases, their perturbed dosage can …

Abdominal fat or fatty liver cause huge economic losses in the poultry industry, and
nonalcoholic fatty liver disease (NAFLD) is also a global health issue in humans. More than …