Critical reanalysis of the mechanisms underlying the cardiorenal benefits of SGLT2 inhibitors and reaffirmation of the nutrient deprivation signaling/autophagy …
M Packer - Circulation, 2022 - Am Heart Assoc
SGLT2 (sodium-glucose cotransporter 2) inhibitors produce a distinctive pattern of benefits
on the evolution and progression of cardiomyopathy and nephropathy, which is …
on the evolution and progression of cardiomyopathy and nephropathy, which is …
SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism
M Packer - Nature Reviews Cardiology, 2023 - nature.com
Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …
direct action on the failing heart that is independent of changes in renal tubular function. In …
Ketones and the heart: metabolic principles and therapeutic implications
The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …
Deranged myocardial fatty acid metabolism in heart failure
T Yamamoto, M Sano - International journal of molecular sciences, 2022 - mdpi.com
The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …
[PDF][PDF] Combination of tofogliflozin and pioglitazone for NAFLD: extension to the ToPiND randomized controlled trial
M Yoneda, T Kobayashi, Y Honda… - Hepatology …, 2022 - Wiley Online Library
The incidence of nonalcoholic fatty liver disease (NAFLD) has recently increased and is
related to obesity and the associated surge in type 2 diabetes mellitus (T2DM) and …
related to obesity and the associated surge in type 2 diabetes mellitus (T2DM) and …
Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart
J Nah, A Shirakabe, R Mukai, P Zhai… - Cardiovascular …, 2022 - academic.oup.com
Aims Well-controlled mitochondrial homeostasis, including a mitochondria-specific form of
autophagy (hereafter referred to as mitophagy), is essential for maintaining cardiac function …
autophagy (hereafter referred to as mitophagy), is essential for maintaining cardiac function …
Ketone bodies for the failing heart: fuels that can fix the engine?
Accumulating evidence suggests that the failing heart reverts energy metabolism toward
increased utilization of ketone bodies. Despite many discrepancies in the literature …
increased utilization of ketone bodies. Despite many discrepancies in the literature …
GSK-3 at the heart of cardiometabolic diseases: Isoform-specific targeting is critical to therapeutic benefit
Abstract Glycogen synthase kinase-3 (GSK-3) is a family of serine/threonine kinases. The
GSK-3 family has 2 isoforms, GSK-3α and GSK-3β. The GSK-3 isoforms have been shown to …
GSK-3 family has 2 isoforms, GSK-3α and GSK-3β. The GSK-3 isoforms have been shown to …
Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice
M Nakamura, MA Keller, N Fefelova, P Zhai… - Nature …, 2023 - nature.com
The anti-apoptotic function of Bcl-xL in the heart during ischemia/reperfusion is diminished
by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows dissociation of Bcl-xL from …
by K-Ras-Mst1-mediated phosphorylation of Ser14, which allows dissociation of Bcl-xL from …
Targeting myocardial substrate metabolism in the failing heart: ready for prime time?
Abstract Purpose of Review We review the clinical benefits of altering myocardial substrate
metabolism in heart failure. Recent Findings Modulation of cardiac substrates (fatty acid …
metabolism in heart failure. Recent Findings Modulation of cardiac substrates (fatty acid …