Predictive biology is the next great chapter in synthetic and systems biology, particularly for
microorganisms. Tasks that once seemed infeasible are increasingly being realized such as …

The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …

Bacteria have evolved multiple secretion systems for delivering effector proteins into the
cytosol of neighboring cells, but the roles of many of these effectors remain unknown. Here …

Highlights•Limitations in molecular resources for gene expression influence bacterial
physiology.•Bacteria optimise trade-offs between resource allocation and growth.•Resource …

The alarming rise in hard-to-treat bacterial infections is of great concern to human health.
Thus, the identification of molecular mechanisms that enable the survival and growth of …

Microbial populations often contain persister cells, which reduce the extinction risk upon
sudden stresses. Persister cell formation is deeply intertwined with physiology. Due to this …

Bacteria are sophisticated systems with high capacity and flexibility to adapt to various
environmental conditions. Each prokaryote however possesses a defined metabolic …

MazEF and MqsRA are toxin-antitoxin systems, where the toxins MazF and MqsR sequence-
specifically cleave single-stranded RNA, thereby shutting down protein synthesis and cell …

Autoregulation is the direct modulation of gene expression by the product of the
corresponding gene. Autoregulation of bacterial gene expression has been mostly studied …

Tryptophan not only serves as a fundamental building block for protein synthesis but also
acts as a metabolic precursor for a diverse array of high-value chemicals. Although a few …