Update on the genetics of primary open-angle glaucoma
Affecting nearly 80 million individuals, glaucoma is the number one cause of irreversible
blindness in the world. This ocular disease describes a set of optic neuropathies of which …
blindness in the world. This ocular disease describes a set of optic neuropathies of which …
Clinical implications of recent advances in primary open-angle glaucoma genetics
H Choquet, JL Wiggs, AP Khawaja - Eye, 2020 - nature.com
Over the last decade, genetic studies, including genome-wide association studies (GWAS),
have accelerated the discovery of genes and genomic regions contributing to primary open …
have accelerated the discovery of genes and genomic regions contributing to primary open …
Comparing the rates of retinal nerve fiber layer and ganglion cell–inner plexiform layer loss in healthy eyes and in glaucoma eyes
Purpose To compare the rates of circumpapillary retinal nerve fiber layer (RNFL) and
macular retinal ganglion cell–inner plexiform layer (GCIPL) change over time in healthy and …
macular retinal ganglion cell–inner plexiform layer (GCIPL) change over time in healthy and …
Clinical factors associated with long-term OCT variability in glaucoma
PURPOSE To examine clinical factors associated with long-term optical coherence
tomography (OCT)–measured retinal nerve fiber layer thickness (RNFLT) variability in …
tomography (OCT)–measured retinal nerve fiber layer thickness (RNFLT) variability in …
Inter-eye asymmetry of optical coherence tomography angiography vessel density in bilateral glaucoma, glaucoma suspect, and healthy eyes
Purpose To investigate inter-eye retinal vessel density asymmetry in healthy, glaucoma
suspect, and mild-to-moderate glaucoma subjects, and its potential utility for early detection …
suspect, and mild-to-moderate glaucoma subjects, and its potential utility for early detection …
A multiethnic genome-wide analysis of 44,039 individuals identifies 41 new loci associated with central corneal thickness
H Choquet, RB Melles, J Yin, TJ Hoffmann… - Communications …, 2020 - nature.com
Central corneal thickness (CCT) is one of the most heritable human traits, with broad-sense
heritability estimates ranging between 0.68 to 0.95. Despite the high heritability and …
heritability estimates ranging between 0.68 to 0.95. Despite the high heritability and …
Genetic architecture of primary open-angle glaucoma in individuals of African descent: the African Descent and Glaucoma Evaluation Study III
Purpose To find genetic contributions to glaucoma in African Americans. Design Cross-
sectional, case-control study. Participants One thousand eight hundred seventy-five primary …
sectional, case-control study. Participants One thousand eight hundred seventy-five primary …
[HTML][HTML] Cohort study of race/ethnicity and incident primary open-angle glaucoma characterized by autonomously determined visual field loss patterns
Purpose: We evaluated racial/ethnic differences in primary open-angle glaucoma (POAG)
defined by machine-learning–derived regional visual field (VF) loss patterns. Methods …
defined by machine-learning–derived regional visual field (VF) loss patterns. Methods …
Ganglion cell-inner plexiform layer and retinal nerve fiber layer changes in glaucoma suspects enable prediction of glaucoma development
JW Shin, KR Sung, MK Song - American Journal of Ophthalmology, 2020 - Elsevier
Purpose To investigate whether progressive macular ganglion cell-inner plexiform layer
(GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thinning predict development of …
(GCIPL) and peripapillary retinal nerve fiber layer (RNFL) thinning predict development of …
Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents
Background To examine long-term retinal nerve fibre layer thickness (RNFLT) variability and
associated clinical factors in African (AD) and European descent (ED) individuals with …
associated clinical factors in African (AD) and European descent (ED) individuals with …