Paracetamol–An old drug with new mechanisms of action
GW Przybyła, KA Szychowski… - Clinical and Experimental …, 2021 - Wiley Online Library
Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …
the world. Despite its popularity and use for many years, the safety of its application and its …
COX-2 in liver fibrosis
H Yang, Y Xuefeng, W Shandong, X Jianhua - Clinica chimica acta, 2020 - Elsevier
As a vital inducible sensor, cyclooxygenase-2 (COX-2) plays an important role in the
progress of hepatic fibrogenesis. Activation of hepatic stellate cells (HSCs) in the liver can …
progress of hepatic fibrogenesis. Activation of hepatic stellate cells (HSCs) in the liver can …
COVID-19. Pandemic surgery guidance
Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …
protecting patients as well as healthcare staff and hereby provide this Guidance to address …
[HTML][HTML] Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward
MR Jennings, D Munn, J Blazeck - Journal for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Tumors accumulate metabolites that deactivate infiltrating immune cells and polarize them
toward anti-inflammatory phenotypes. We provide a comprehensive review of the complex …
toward anti-inflammatory phenotypes. We provide a comprehensive review of the complex …
Interplay between oxidative stress, cyclooxygenases, and prostanoids in cardiovascular diseases
Significance: Endothelial cells lining the lumen of blood vessels play an important role in the
regulation of cardiovascular functions through releasing both vasoconstricting and …
regulation of cardiovascular functions through releasing both vasoconstricting and …
An update of cyclooxygenase (COX)-inhibitors in epilepsy disorders
A Dhir - Expert Opinion on Investigational Drugs, 2019 - Taylor & Francis
Introduction: Neuroinflammation has a critical role in brain disorders. Cyclooxygenase
(COX) is one of the principal drug targets for the reduction of neuroinflammation; however …
(COX) is one of the principal drug targets for the reduction of neuroinflammation; however …
Natural product inhibitors of cyclooxygenase (COX) enzyme: A review on current status and future perspectives
GG Ambati, SM Jachak - Current Medicinal Chemistry, 2021 - ingentaconnect.com
Background: Several clinically used COX-1 and COX-2 inhibitor drugs were reported to
possess severe side effects like GI ulcers and cardiovascular disturbances, respectively …
possess severe side effects like GI ulcers and cardiovascular disturbances, respectively …
Phytochemical mediated modulation of COX-3 and NFκB for the management and treatment of arthritis
In this study, we investigated whether zerumbone (ZBN), ellagic acid (ELA) and quercetin
(QCT), the plant-derived components, can modulate the role of COX-3 or cytokines liable in …
(QCT), the plant-derived components, can modulate the role of COX-3 or cytokines liable in …
[PDF][PDF] The cyclooxygenase-2/prostaglandin E2 pathway and its role in the pathogenesis of human and dog hematological malignancies.
M Zmigrodzka, A Rzepecka… - Journal of Physiology …, 2018 - researchgate.net
The overexpression of cyclooxygenase-2 (COX-2) has been documented in many types of
cancer occurring in humans and animals. Increasing evidences have shown that the …
cancer occurring in humans and animals. Increasing evidences have shown that the …