R-loop-dependent promoter-proximal termination ensures genome stability

C Xu, C Li, J Chen, Y Xiong, Z Qiao, P Fan, C Li, S Ma… - Nature, 2023 - nature.com
The proper regulation of transcription is essential for maintaining genome integrity and
executing other downstream cellular functions,. Here we identify a stable association …

The anti-DNA antibodies: their specificities for unique DNA structures and their unresolved clinical impact—a system criticism and a hypothesis

OP Rekvig - Frontiers in immunology, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is diagnosed and classified by criteria, or by
experience, intuition and traditions, and not by scientifically well-defined etiology (ies) or …

Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system

MJB Amorim, Y Gansemans, SIL Gomes… - Lab Animal, 2021 - nature.com
Enchytraeids (Annelida) are soil invertebrates with worldwide distribution that have served
as ecotoxicology models for over 20 years. We present the first high-quality reference …

Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres

TP Lippert, P Marzec, AI Idilli, G Sarek… - Nature …, 2021 - nature.com
To achieve replicative immortality, cancer cells must activate telomere maintenance
mechanisms to prevent telomere shortening.~ 85% of cancers circumvent telomeric attrition …

DNA‐dependent phase separation by human SSB2 (NABP1/OBFC2A) protein points to adaptations to eukaryotic genome repair processes

ZJ Kovács, GM Harami, J Pálinkás… - Protein …, 2024 - Wiley Online Library
Single‐stranded DNA binding proteins (SSBs) are ubiquitous across all domains of life and
play essential roles via stabilizing and protecting single‐stranded (ss) DNA as well as …

Effect of silencing SSB1 gene on the expression of NBS1 in irradiated rat submandibular gland cells

L Gao, Q Lv, Y Huang, Y Fan, L Zhao… - Cellular and …, 2024 - mail.cellmolbiol.org
The salivary gland (SGS) is a kind of organ vulnerable to ionizing radiation. Radiotherapy is
an important treatment for head and neck tumors, but in the process of radiotherapy, tumor …

Unraveling BCR:: ABL1-driven enhancer activation and transcriptional reprogramming in Ph B-ALL

HL Ng, TL Glaser, ME Robinson, KN Cosgun… - 2024 - researchsquare.com
B-lineage acute-lymphoblastic leukemia (B-ALL) is driven by genomic lesions and distinct
transcriptional programs. Both are often directly linked as most B-ALLs are caused by …

[引用][C] Az egyszálú DNS-kötő (SSB) fehérjék új szerveződési elve, a folyadék-folyadék fázisszeparáció és szerepe a genomkarbantartásban

Z Kovács - 2022