Review on preventive measures to reduce post-weaning diarrhoea in piglets

N Canibe, O Højberg, H Kongsted, D Vodolazska… - Animals, 2022 - mdpi.com
Simple Summary Post-weaning diarrhoea (PWD) is a major challenge in pig production,
which results in the high use of ZnO for its prevention and the utilisation of antibiotics for its …

Assessing developability early in the discovery process for novel biologics

ML Fernández-Quintero, A Ljungars, F Waibl, V Greiff… - MAbs, 2023 - Taylor & Francis
Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …

Orally delivered single-domain antibodies against gastrointestinal pathogens

M Petersson, SW Thrane, L Gram, S Muyldermans… - Trends in …, 2023 - cell.com
Single-domain antibodies (sdAbs) are exceptionally stable fragments derived from the
antigen-binding domains of immunoglobulins. They can withstand extreme pH, high …

Single Domain Antibody application in bacterial infection diagnosis and neutralization

Q Qin, H Liu, W He, Y Guo, J Zhang, J She… - Frontiers in …, 2022 - frontiersin.org
Increasing antibiotic resistance to bacterial infections causes a serious threat to human
health. Efficient detection and treatment strategies are the keys to preventing and reducing …

Nanobodies: The potential application in bacterial treatment and diagnosis

S Yu, L Zhang, A Wang, Y Jin, D Zhou - Biochemical Pharmacology, 2023 - Elsevier
An infection caused by bacteria is one of the main factors that poses a threat to human
health. A recent report from the World Health Organization (WHO) has highlighted that …

Single domain antibody: Development and application in biotechnology and biopharma

T Yu, F Zheng, W He, S Muyldermans… - Immunological …, 2024 - Wiley Online Library
Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and
comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a …

Protecting the piglet gut microbiota against ETEC-mediated post-weaning diarrhoea using specific binding proteins

TP Jenkins, N Ács, EW Arendrup, A Swift… - npj Biofilms and …, 2024 - nature.com
Post-weaning diarrhoea (PWD) in piglets presents a widespread problem in industrial pig
production and is often caused by enterotoxigenic E. coli (ETEC) strains. Current solutions …

Food-Borne Biotoxin Neutralization in Vivo by Nanobodies: Current Status and Prospects

ML Liu, XM Liang, MY Jin, HW Huang… - Journal of Agricultural …, 2024 - ACS Publications
Food-borne biotoxins from microbes, plants, or animals contaminate unclean, spoiled, and
rotten foods, posing significant health risks. Neutralizing such toxins is vital for human …

Development of a bispecific Nanobody anti-F17 fimbria as a potential therapeutic tool

A Dhehibi, M Terrak, MM Seddik, M Hammadi… - Protein Expression and …, 2024 - Elsevier
Pathogenic strains of Escherichia coli F17+ are associated with various intestinal and extra-
intestinal pathologies, including diarrhea, and result in significant animal mortality. These …

Fit‐for‐purpose heterodivalent single‐domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile

ER Rodriguez Rodriguez, RT Nordvang… - Protein …, 2024 - Wiley Online Library
Abstract Single‐domain antibodies (sdAbs), such as VHHs, are increasingly being
developed for gastrointestinal (GI) applications against pathogens to strengthen gut health …