The tumor microenvironment (TME) orchestrates a complex interplay between tumor cells
and immune cells, crucially modulating the immune response. This review delves into the …

With further research into the molecular mechanisms and roles linking immune suppression
and restraint of (pre) malignancies, immunotherapies have revolutionized clinical strategies …

Introduction: There is a vicious cycle of tumor hypoxia, high adenosine levels, immune
suppression and cancer growth that involves the use of adenosine receptor ligands in …

G protein-coupled receptors (GPCRs) not only exist as monomers but also as homomers
and heteromers in which allosteric receptor-receptor interactions take place, modulating the …

With the aim to obtain potent adenosine A 2A receptor (A 2A R) ligands, a series of eighteen
derivatives of 4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1, 3-benzo [d] thiazol-2-yl)-4 …

Renal cell carcinoma (RCC) accounts for nearly 2% of cancers diagnosed worldwide. For
metastatic RCC, targeted therapy is one of the most common treatment methods. It can …

Ischemic stroke is a complex systemic disease characterized by high morbidity, disability,
and mortality. The activation of the presynaptic adenosine A2A and A1 receptors modifies a …

Adenosine is an endogenous modulator exerting its physiological effects by activating four A
1, A 2A, A 2B, and A 3 adenosine receptors. This nucleoside increases in hypoxia that …

Background There are several studies that indicate that cancer development may be
conditioned by the activation of some biological systems that involve the interaction of …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
61911575&utm_source= google_patent&utm_medium= platform_link&utm_campaign …