Ovarian sex cord-stromal tumors: an update on clinical features, molecular changes, and management

R Al Harbi, IA McNeish, M El-Bahrawy - International Journal of …, 2021 - ijgc.bmj.com
Sex cord stromal-tumors are rare tumors of the ovary that include numerous tumor subtypes
of variable histological features and biological behavior. Surgery is the main therapeutic …

The adiponectin agonist, AdipoRon, inhibits steroidogenesis and cell proliferation in human luteinized granulosa cells

J Grandhaye, S Hmadeh, I Plotton, F Levasseur… - Molecular and cellular …, 2021 - Elsevier
During obesity, excess body weight is not only associated with an increased risk of type 2-
diabetes, but also several other pathological processes, such as infertility. Adipose tissue is …

Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells

M Kaseder, N Schmid, K Eubler, K Goetz… - Molecular human …, 2022 - academic.oup.com
In the ovary, proliferation and differentiation of granulosa cells (GCs) drive follicular growth.
Our immunohistochemical study in a non-human primate, the Rhesus monkey, showed that …

RIPK1 and RIPK3 are positive prognosticators for cervical cancer patients and C2 ceramide can inhibit tumor cell proliferation in vitro

TLR Vogelsang, V Kast, K Bagnjuk, K Eubler… - Frontiers in …, 2023 - frontiersin.org
Introduction The enzymes Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
und 3 (RIPK3) as well as the protein Mixed lineage kinase domain like pseudokinase …

Advanced Granulosa Cell Tumors of the Ovary: A Review with a Focus on Current and Novel Therapeutic Approaches

MA Salkeni, S Shin, N Takebe… - Journal of …, 2024 - meridian.allenpress.com
Granulosa cell tumor (GCT) is the most common nonepithelial ovarian malignancy. Still, it is
considered rare, with a paucity of high-level evidence guiding management, particularly in …

Sirtuin 1 and Sirtuin 3 in granulosa cell tumors

N Schmid, KG Dietrich, I Forne, A Burges… - International Journal of …, 2021 - mdpi.com
Sirtuins (SIRTs) are NAD+-dependent deacetylases that regulate proliferation and cell
death. In the human ovary, granulosa cells express sirtuin 1 (SIRT1), which has also been …

[HTML][HTML] The correlation between Smac, IAPs and mitochondrial apoptosis, muscle tenderness during postmortem aging of Oula Tibetan sheep meat

J Wang, R Zhao, Y Liu, T Hu, X Li, L He, Z Guo… - Food Chemistry: X, 2024 - Elsevier
Oula Tibetan sheep meat has rich nutritional value but relatively poor tenderness. Recently,
apoptosis of muscle cells has gradually become a research hotspot for improving meat …

Identification of core differentially methylated genes in glioma

J Xue, HX Gao, W Sang, WL Cui, M Liu… - Oncology …, 2019 - spandidos-publications.com
Differentially methylated genes (DMGs) serve a crucial role in the pathogenesis of glioma
via the regulation of the cell cycle, proliferation, apoptosis, migration, infiltration, DNA repair …

Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic

MA Miles, S Caruso, AA Baxter, IKH Poon, CJ Hawkins - Apoptosis, 2020 - Springer
Smac mimetics, or IAP antagonists, are a class of drugs currently being evaluated as anti-
cancer therapeutics. These agents antagonize IAP proteins, including cIAP1/2 and XIAP, to …

[HTML][HTML] Intraarticular injection of SHP2 inhibitor SHP099 promotes the repair of rabbit full-thickness cartilage defect

Z Sun, X Xu, Z Lv, J Li, T Shi, H Sun, K Sun… - Journal of Orthopaedic …, 2022 - Elsevier
Background Cartilage repair has been a challenge in the field of orthopaedics for decades,
highlighting the significance of investigating potential therapeutic drugs. In this study, we …