Abstract Purpose of Review Hyperbilirubinemia is commonly seen in neonates. Though
hyperbilirubinemia is typically asymptomatic, severe elevation of bilirubin levels can lead to …

Previously in Part I of this two-part review, we discussed the current and recent advances in
the understanding of the molecular biology and neuropathology of bilirubin neurotoxicity …

Crigler‐Najjar syndrome type I (CNSI) is a rare monogenic disease characterized by severe
neonatal unconjugated hyperbilirubinemia with a lifelong risk of neurological damage and …

Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels.
However, at high concentrations, it produces severe neurological damage and death …

Nonintegrative AAV-mediated gene therapy in the liver is effective in adult patients but faces
limitations in pediatric settings because of episomal DNA loss during hepatocyte …

Hyperbilirubinemia (jaundice) is caused by raised levels of unconjugated bilirubin in the
blood. When severe, susceptible brain regions including the cerebellum and auditory …

Hyperbilirubinaemia is a prevalent condition during the neonatal period, and if not promptly
and effectively managed, it can lead to severe bilirubin-induced neurotoxicity. Sunflower …

Crigler-Najjar syndrome is a severe metabolic disease of the liver due to a reduced activity
of the UDP Glucuronosyltransferase 1A1 (UGT1A1) enzyme. In an effort to translate to the …

All pre-term newborns and a high proportion of term newborns develop neonatal jaundice.
Neonatal jaundice is usually a benign condition and self-resolves within few days after birth …

Objective Jaundice (icterus) is the visible manifestation of the accumulation of bilirubin in the
tissue and is indicative of potential toxicity to the brain. Since its very first description more …