Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Human cytochrome P450 (CYP) enzymes play a key role in the metabolism of drugs and
environmental chemicals. Several CYP enzymes metabolically activate procarcinogens to …

Gynecological malignancies are a female type of cancers that affects the reproductive
system. Cancer metastasis or recurrence mediated by cellular invasiveness occurs at …

Abstract Cytochrome P-450 (CYP) 1A1 plays a key role in phase I metabolism of polycyclic
aromatic hydrocarbons and in estrogen metabolism. It is expressed predominantly in …

DNA repair gene polymorphisms and mutations are known to influence cancer risk. We
studied whether polymorphisms in DNA double strand break (DSB) repair genes are …

Much of the interindividual variability in drug response is attributable to the presence of
single nucleotide polymorphisms (SNPs) in genes encoding drug-metabolizing enzymes …

Several epidemiologic studies associate certain CYP1A1 genotypes, alone or in
combination, with an increased risk of estrogen-related cancers. To answer the question of …

Over the past decade, there have been significant developments in treatment for ovarian
cancer, yet the lack of targeted therapy with few side effects still represents a major issue …

Given that there are millions of single-nucleotide polymorphisms (SNPs) in the entire human
genome, a major difficulty faced by scientists in planning costly population-based …

In this study, we evaluated the effect of polymorphisms of the CYP1A1 gene, linked to
hormone‐related cancers, on estrogen metabolism and BMD. We found that variants …