The tuberculous granuloma: an unsuccessful host defence mechanism providing a safety shelter for the bacteria?

M Silva Miranda, A Breiman, S Allain… - Journal of …, 2012 - Wiley Online Library
One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …

Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors

CV Harding, WH Boom - Nature Reviews Microbiology, 2010 - nature.com
Mycobacterium tuberculosis survives in antigen-presenting cells (APCs) such as
macrophages and dendritic cells. APCs present antigens in association with major …

MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

DME Bowdish, K Sakamoto, MJ Kim, M Kroos… - PLoS …, 2009 - journals.plos.org
Virtually all of the elements of Mycobacterium tuberculosis (Mtb) pathogenesis, including pro-
inflammatory cytokine production, granuloma formation, cachexia, and mortality, can be …

The Pathology of Mycobacterium tuberculosis Infection

K Sakamoto - Veterinary pathology, 2012 - journals.sagepub.com
Mycobacterium tuberculosis is an old enemy of the human race, with evidence of infection
observed as early as 5000 years ago. Although more host-restricted than Mycobacterium …

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung

EE Thornton, MR Looney, O Bose, D Sen… - Journal of Experimental …, 2012 - rupress.org
Asthma pathogenesis is focused around conducting airways. The reasons for this focus
have been unclear because it has not been possible to track the sites and timing of antigen …

Early T‐cell responses in tuberculosis immunity

GM Winslow, A Cooper, W Reiley… - Immunological …, 2008 - Wiley Online Library
Tuberculosis (TB) has plagued mankind for millennia yet is classified as an emerging
infectious disease, because its prevalence in the human population continues to increase …

[HTML][HTML] A role for dendritic cells in the dissemination of mycobacterial infection

IR Humphreys, GR Stewart, DJ Turner, J Patel… - Microbes and …, 2006 - Elsevier
The ability of mycobacteria to disseminate from the initial site of infection has an important
role in immune priming and in the seeding of disease in multiple organs. To study this …

Interplay between alveolar epithelial and dendritic cells and Mycobacterium tuberculosis

TS Rodrigues, BJ Conti, TFC Fraga-Silva… - Journal of Leucocyte …, 2020 - academic.oup.com
The innate response plays a crucial role in the protection against tuberculosis development.
Moreover, the initial steps that drive the host-pathogen interaction following Mycobacterium …

In vivo role of dendritic cells in a murine model of pulmonary cryptococcosis

KL Wozniak, JM Vyas, SM Levitz - Infection and immunity, 2006 - Am Soc Microbiol
Dendritic cells (DC) have been shown to phagocytose and kill Cryptococcus neoformans in
vitro and are believed to be important for inducing protective immunity against this organism …

MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage

NTT Thuong, TTB Tram, TD Dinh, PVK Thai… - Genes & …, 2016 - nature.com
Macrophage receptor with collagenous structure (MARCO) has an important role in the
phagocytosis of Mycobacterium tuberculosis (M. tuberculosis). We hypothesized that …