The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Ingestion of omega-3 fatty acids is known to exert favorable health effects on a number of
biological processes such as improved immune profile, enhanced cognition, and optimized …

Long-chain fatty acids are molecules that act as metabolic intermediates and constituents of
membranes; however, their novel role as signaling molecules in immune function has also …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …

The composition of fatty acids in the diets of both human and domestic animal species can
regulate inflammation through the biosynthesis of potent lipid mediators. The substrates for …

Free fatty acids (FFAs) are energy-generating nutrients that act as signaling molecules in
various cellular processes. Several orphan G protein-coupled receptors (GPCRs) that act as …

The understanding of how osteoclasts are generated and whether they can be altered by
inflammatory stimuli is a topic of particular interest for osteoclastogenesis. It is known that the …

Over the last decade, a subfamily of G protein-coupled receptors that are agonized by
endogenous and dietary free-fatty acids (FFA) has been discovered. These free-fatty acid …

Various foods are associated with effects against metabolic diseases such as insulin
resistance and type 2 diabetes; however, their mechanisms of action are mostly unclear …

The prevalence of obesity and type 2 diabetes (T2D) is increasing worldwide, and these two
metabolic disorders are closely linked. Lifestyle modification, including weight loss and …