[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …
Molecular and cellular mechanisms of tooth development, homeostasis and repair
T Yu, OD Klein - Development, 2020 - journals.biologists.com
The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …
organogenesis, and has thus been of longstanding interest to developmental and stem cell …
Wnt Signaling in vascular eye diseases
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …
Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis
M Yu, SW Wong, D Han, T Cai - Oral diseases, 2019 - Wiley Online Library
Tooth agenesis (TA) is one of the most common developmental anomalies that affects the
number of teeth. An extensive analysis of publicly accessible databases revealed 15 …
number of teeth. An extensive analysis of publicly accessible databases revealed 15 …
[HTML][HTML] Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders
Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …
[HTML][HTML] Molecular genetics and targeted therapy of WNT-related human diseases
M Katoh, M Katoh - International journal of …, 2017 - … .spandidos-publications.com
Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …
WNT/β-catenin and WNT/stabilization of proteins (STOP) signaling cascades to regulate cell …
Intertwined signaling pathways governing tooth development: a give-and-take between canonical Wnt and Shh
F Hermans, L Hemeryck, I Lambrichts… - Frontiers in cell and …, 2021 - frontiersin.org
Teeth play essential roles in life. Their development relies on reciprocal interactions
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …
between the ectoderm-derived dental epithelium and the underlying neural crest-originated …
[HTML][HTML] Intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency
Background & Aims Congenital diarrheal disorders are rare inherited intestinal disorders
characterized by intractable, sometimes life-threatening, diarrhea and nutrient …
characterized by intractable, sometimes life-threatening, diarrhea and nutrient …
Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models
K Reynolds, P Kumari… - Disease models & …, 2019 - journals.biologists.com
Diverse signaling cues and attendant proteins work together during organogenesis,
including craniofacial development. Lip and palate formation starts as early as the fourth …
including craniofacial development. Lip and palate formation starts as early as the fourth …
Whole exome sequencing identifies mutations in 10% of patients with familial non-syndromic cleft lip and/or palate in genes mutated in well-known syndromes
Background Oral clefts, that is, clefts of the lip and/or cleft palate (CL/P), are the most
common craniofacial birth defects with an approximate incidence of~ 1/700. To date …
common craniofacial birth defects with an approximate incidence of~ 1/700. To date …