Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Building better biomarkers: brain models in translational neuroimaging
Despite its great promise, neuroimaging has yet to substantially impact clinical practice and
public health. However, a developing synergy between emerging analysis techniques and …
public health. However, a developing synergy between emerging analysis techniques and …
A distributed fMRI-based signature for the subjective experience of fear
The specific neural systems underlying the subjective feeling of fear are debated in affective
neuroscience. Here, we combine functional MRI with machine learning to identify and …
neuroscience. Here, we combine functional MRI with machine learning to identify and …
Evidence for embracing normative modeling
In this work, we expand the normative model repository introduced in Rutherford et al.,
2022a to include normative models charting lifespan trajectories of structural surface area …
2022a to include normative models charting lifespan trajectories of structural surface area …
A network model of the emotional brain
L Pessoa - Trends in cognitive sciences, 2017 - cell.com
Emotion is often understood in terms of a circumscribed set of cortical and subcortical brain
regions. I propose, instead, that emotion should be understood in terms of large-scale …
regions. I propose, instead, that emotion should be understood in terms of large-scale …
The relation between statistical power and inference in fMRI
Statistically underpowered studies can result in experimental failure even when all other
experimental considerations have been addressed impeccably. In fMRI the combination of a …
experimental considerations have been addressed impeccably. In fMRI the combination of a …
The experiences of individuals with cervical spinal cord injury and their family during post-injury care in non-specialised and specialised units in UK
J McRae, C Smith, A Emmanuel, S Beeke - BMC health services research, 2020 - Springer
Background Individuals with acute cervical spinal cord injury require specialised
interventions to ensure optimal clinical outcomes especially for respiratory, swallowing and …
interventions to ensure optimal clinical outcomes especially for respiratory, swallowing and …
Social, self,(situational), and affective processes in medial prefrontal cortex (MPFC): Causal, multivariate, and reverse inference evidence
The medial prefrontal cortex (MPFC) has been posited to serve a variety of social, affective,
and cognitive functions. These conclusions have largely been driven by forward inference …
and cognitive functions. These conclusions have largely been driven by forward inference …
Decoding the nature of emotion in the brain
A central, unresolved problem in affective neuroscience is understanding how emotions are
represented in nervous system activity. After prior localization approaches largely failed …
represented in nervous system activity. After prior localization approaches largely failed …
Brain imaging tests for chronic pain: medical, legal and ethical issues and recommendations
Chronic pain is the greatest source of disability globally and claims related to chronic pain
feature in many insurance and medico-legal cases. Brain imaging (for example, functional …
feature in many insurance and medico-legal cases. Brain imaging (for example, functional …