Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action
of eicosanoids in different physiological systems, the roles of eicosanoids in selected …

Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …

Specialized pro-resolving mediators (SPMs) are enzymatically derived from essential fatty
acids and have important roles in orchestrating the resolution of tissue inflammation—that is …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …

Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …

Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant
economic and clinical impact. While an inflammatory response upon injury is necessary to …

Chronic inflammation is a central pathogenic mechanism of atherosclerosis induction and
progression. Vascular inflammation is associated with accelerated onset of late …