Anticancer drugs: How to select small molecule combinations?
R Nussinov, BR Yavuz, H Jang - Trends in Pharmacological Sciences, 2024 - cell.com
Small molecules are at the forefront of anticancer therapies. Successive treatments with
single molecules incur drug resistance, calling for combination. Here, we explore the tough …
single molecules incur drug resistance, calling for combination. Here, we explore the tough …
Lysine and arginine methylation of transcription factors
BD Giaimo, F Ferrante, T Borggrefe - Cellular and Molecular Life Sciences, 2024 - Springer
Post-translational modifications (PTMs) are implicated in many biological processes
including receptor activation, signal transduction, transcriptional regulation and protein …
including receptor activation, signal transduction, transcriptional regulation and protein …
Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive …
Rhabdomyosarcoma (RMS), a malignancy of impaired myogenic differentiation, is the most
common soft tissue pediatric cancer. PAX3-FOXO1 oncofusions drive the majority of the …
common soft tissue pediatric cancer. PAX3-FOXO1 oncofusions drive the majority of the …
Epigenetic determinants of fusion-driven sarcomas: paradigms and challenges
BZ Stanton, S Pomella - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
We describe exciting recent advances in fusion-driven sarcoma etiology, from an
epigenetics perspective. By exploring the current state of the field, we identify and describe …
epigenetics perspective. By exploring the current state of the field, we identify and describe …
Inhibition of Mdm2-p53 interaction as a therapeutic strategy for the treatment of p53 wild-type rhabdomyosarcoma
G Pons Barcons - tdx.cat
Targeting MDM2-p53 interaction to enhance p53 activity represents a potentially attractive
antitumoral approach for p53 wild-type tumors. However, results from early-phase clinical …
antitumoral approach for p53 wild-type tumors. However, results from early-phase clinical …