Ten challenges for clinical translation in psychiatric genetics

EM Derks, JG Thorp, ZF Gerring - Nature Genetics, 2022 - nature.com
Genome-wide association studies have identified hundreds of robust genetic associations
underlying psychiatric disorders and provided important biological insights into disease …

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies

N Cai, KW Choi, EI Fried - Human molecular genetics, 2020 - academic.oup.com
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

Y Milaneschi, N Kappelmann, Z Ye, F Lamers… - Molecular …, 2021 - nature.com
We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

AD Grotzinger, TT Mallard, WA Akingbuwa, HF Ip… - Nature …, 2022 - nature.com
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …

Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

JG Thorp, AI Campos, AD Grotzinger… - Nature human …, 2021 - nature.com
Depression and anxiety are highly prevalent and comorbid psychiatric traits that cause
considerable burden worldwide. Here we use factor analysis and genomic structural …

Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies

MA Waszczuk, KG Jonas, M Bornovalova, G Breen… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …

Genome-wide association study meta-analysis of suicide death and suicidal behavior

QS Li, AA Shabalin, E DiBlasi, S Gopal… - Molecular …, 2023 - nature.com
Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …

Genetic heterogeneity and subtypes of major depression

TD Nguyen, A Harder, Y Xiong, K Kowalec… - Molecular …, 2022 - nature.com
Major depression (MD) is a heterogeneous disorder; however, the extent to which genetic
factors distinguish MD patient subgroups (genetic heterogeneity) remains uncertain. This …

Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank

AI Campos, LM García-Marín, EM Byrne… - Nature …, 2020 - nature.com
Although snoring is common in the general population, its aetiology has been largely
understudied. Here we report a genetic study on snoring (n~ 408,000; snorers~ 152,000) …

Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration

I Austin-Zimmerman, DF Levey… - Nature …, 2023 - nature.com
Sleep duration has been linked to a wide range of negative health outcomes and to reduced
life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ …