Organoids are miniature, highly accurate representations of organs that capture the structure
and unique functions of specific organs. Although the field of organoids has experienced …

Pancreatic ductal adenocarcinoma (PDAC) ranks among the leading causes of cancer‐
related deaths worldwide. Despite advances in precision oncology in other malignancies …

Computational biology involves applying computer science and informatics techniques in
biology to understand complex biological data. It allows us to collect, connect, and analyze …

Organoids, self-organized structures derived from stem cells cultured in a specific three-
dimensional (3D) in vitro microenvironment, have emerged as innovative platforms that …

Animal models have been extensively used as a gold standard in various biological
research, including immunological studies. Despite high availability and ease of handling …

Highlights•Relevance of organoid cultures in cerebral disease modeling.•Review of
organoid and stem cell engineering principles.•Examples for engineered cerebral disease …

Background: Organoids are 3D in vitro models that fulfill a hierarchical function, representing
a small version of living tissues and, therefore, a good approximation of cellular …

Multiple sclerosis (MS), a debilitating autoimmune disorder targeting the central nervous
system (CNS), is marked by relentless demyelination and inflammation. Clinically, it …

One of the most remarkable properties of the brain is the ability to construct representations
of the external environment, which can be used to simulate and plan future interactions. In …

Melanoma is a very aggressive, rapidly metastasizing tumor that has been studied
intensively in the past regarding the underlying genetic and molecular mechanisms. More …