As the incidence of hepatobiliary diseases increases, we must improve our understanding of
the molecular, cellular, and physiological factors that contribute to the pathogenesis of liver …

The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via
its endocrine and exocrine functions. Here we review the essential processes governing the …

TCF3-HLF− positive acute lymphoblastic leukemia (ALL) is currently incurable. Using an
integrated approach, we uncovered distinct mutation, gene expression and drug response …

How are closely related lineages, including liver, pancreas, and intestines, diversified from a
common endodermal origin? Here, we apply principles learned from developmental biology …

Control of both tissue architecture and scale is a fundamental translational roadblock in
tissue engineering. An experimental framework that enables investigation into how …

Background The relationship between pancreatic cancer (PC) and type 2 diabetes mellitus
(T2DM) has long been widely recognized, but the interaction mechanisms are still unknown …

Soybean oil consumption is increasing worldwide and parallels a rise in obesity. Rich in
unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it …

Blood flow promotes emergence of definitive hematopoietic stem cells (HSCs) in the
developing embryo, yet the signals generated by hemodynamic forces that influence …

During coordinated development of two neighboring organs from the same germ layer, how
precursors of one organ resist the inductive signals of the other to avoid being misinduced to …

Prostaglandins are well known to be central regulators of vertebrate ovulation. Studies
addressing the role of prostaglandins in mammalian ovulation have established that they …