T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM
family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and …

The blockade of immune checkpoint receptors has made great strides in the treatment of
major cancers, including melanoma, Hodgkin's lymphoma, renal, and lung cancer. However …

Leishmania is a genus of protozoan parasites that are transmitted by the bite of
phlebotomine sandflies and give rise to a range of diseases (collectively known as …

The discovery of the carcinoembryonic antigen (CEA) as a tumor marker for colorectal
cancer some 50 years ago became the first step in the identification of a much larger family …

Sarcomas are a group of diverse and complex cancers of mesenchymal origin that remains
poorly understood. Recent developments in cancer immunotherapy have demonstrated a …

The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Since immune cells represent a large fraction of the TME, they play a key role in …

Introduction Dysfunction of the immune system is a hallmark of cancer. Through increased
understanding of the complex interactions between immunity and cancer, immunotherapy …

Antigen presentation by cells of the vessel wall may initiate rapid and localized memory
immune responses in peripheral tissues. Peptide antigens displayed on major …

Abstract Purpose of Review Even though checkpoint inhibitors have become a recent
milestone for the treatment of many different tumor types, eventually, most part of patients …

The eye and the brain are immunologically privileged sites, a property previously attributed
to the lack of a lymphatic circulation. However, recent tracking studies confirm that these …