[HTML][HTML] Neurostimulation as a putative method for the treatment of drug-resistant epilepsy in patient and animal models of epilepsy
F Bakhtiarzadeh, M Zare, Z Ghasemi… - Basic and Clinical …, 2023 - ncbi.nlm.nih.gov
A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and
social issues as a result of recurring seizures, which is regarded as a chronic brain disease …
social issues as a result of recurring seizures, which is regarded as a chronic brain disease …
Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test
Epileptic seizures are characterized with cognitive disorders. In this study we investigated
the effect of electrical low frequency stimulation (LFS), as a potential anticonvulsant agent …
the effect of electrical low frequency stimulation (LFS), as a potential anticonvulsant agent …
Epilepsy and dopaminergic system
Epilepsy is accompanied with a strong change in neuronal activity not only in excitatory
(glutamatergic) and inhibitory (GABAergic) neurotransmission, but also in neuromodulatory …
(glutamatergic) and inhibitory (GABAergic) neurotransmission, but also in neuromodulatory …
Subicular pyramidal neurons gate drug resistance in temporal lobe epilepsy
Objective Drug‐resistant epilepsy causes great clinical danger and still lacks effective
treatments. Methods Here, we used multifaceted approaches combining electrophysiology …
treatments. Methods Here, we used multifaceted approaches combining electrophysiology …
Effect of low frequency electrical stimulation on seizure-induced short-and long-term impairments in learning and memory in rats
Kindled seizures can impair learning and memory. In the present study the effect of low-
frequency electrical stimulation (LFS) on kindled seizure-induced impairment in spatial …
frequency electrical stimulation (LFS) on kindled seizure-induced impairment in spatial …
Short-term epileptiform activity potentiates excitatory synapses but does not affect intrinsic membrane properties of pyramidal neurons in the rat hippocampus in vitro
JL Ergina, DV Amakhin, TY Postnikova, EB Soboleva… - Biomedicines, 2021 - mdpi.com
Even brief epileptic seizures can lead to activity-dependent structural remodeling of neural
circuitry. Animal models show that the functional plasticity of synapses and changes in the …
circuitry. Animal models show that the functional plasticity of synapses and changes in the …
Effect of the closed‐loop hippocampal low‐frequency stimulation on seizure severity, learning, and memory in pilocarpine epilepsy rat model
Aims In this study, the anticonvulsant action of closed‐loop, low‐frequency deep brain
stimulation (DBS) was investigated. In addition, the changes in brain rhythms and functional …
stimulation (DBS) was investigated. In addition, the changes in brain rhythms and functional …
The Glycolysis Inhibitor 2-Deoxy-d-Glucose Exerts Different Neuronal Effects at Circuit and Cellular Levels, Partially Reverses Behavioral Alterations and does not …
Temporal lobe epilepsy is the most drug-resistant type with the highest incidence among the
other focal epilepsies. Metabolic manipulations are of great interest among others, glycolysis …
other focal epilepsies. Metabolic manipulations are of great interest among others, glycolysis …
Amygdala low-frequency stimulation reduces pathological phase-amplitude coupling in the pilocarpine model of epilepsy
Temporal-lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy and
warrants the development of new therapies, such as deep-brain stimulation (DBS). DBS was …
warrants the development of new therapies, such as deep-brain stimulation (DBS). DBS was …
[HTML][HTML] Long-term effects of hippocampal low-frequency stimulation on pro-inflammatory factors and astrocytes activity in kindled rats
R Rohani, A Aliaghaei, MA Abdollahifar… - Cell Journal …, 2021 - ncbi.nlm.nih.gov
Objective Epilepsy is accompanied by inflammation, and the anti-inflammatory agents may
have anti-seizure effects. In this investigation, the effect of deep brain stimulation, as a …
have anti-seizure effects. In this investigation, the effect of deep brain stimulation, as a …