Objective Critical limb ischemia (CLI) is associated with high morbidity and mortality.
Because most patients with CLI will eventually undergo some type of revascularization, the …

Critical limb ischemia (CLI) is considered the most severe pattern of peripheral artery
disease. It is defined by the presence of chronic ischemic rest pain, ulceration or gangrene …

Guideline Summary Chronic limb-threatening ischemia (CLTI) is associated with mortality,
amputation, and impaired quality of life. These Global Vascular Guidelines (GVG) are …

Critical limb ischemia, first defined in 1982, was intended to delineate a subgroup of patients
with a threatened lower extremity primarily because of chronic ischemia. It was the intent of …

Critical limb ischemia (CLI), which is at the end of the peripheral artery disease (PAD)
spectrum, is associated with excessively high risk for cardiovascular events, including …

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes.
HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility …

Peripheral arterial disease (PAD) is caused by occlusive atherosclerosis in a vascular bed
other than the heart. The lower extremity is the most-common location for PAD. Critical limb …

Cardiovascular diseases remain a large global health problem. Although several
conventional small-molecule treatments are available for common cardiovascular problems …

Critical limb ischemia (CLI) continues to be a significantly morbid disease process for the
aging population. Rigid guidelines for the management of patients with CLI are …

OBJECTIVE: To develop a set of suggested objective performance goals (OPG) for
evaluating new catheter-based treatments in critical limb ischemia (CLI), based on evidence …