Advancing d-amino acid-containing peptide discovery in the metazoan
The discovery of enzyme-derived d-amino acid-containing peptides (DAACPs) that have
physiological importance in the metazoan challenges previous assumptions about the …
physiological importance in the metazoan challenges previous assumptions about the …
Programmed Aptamer Screening, Characterization, and Rapid Detection for α-Conotoxin MI
H Guo, B Deng, L Zhao, Y Gao, X Zhang, C Yang… - Toxins, 2022 - mdpi.com
Conotoxins (CTXs) are a variety of mixed polypeptide toxins, among which α-conotoxin MI
(CTX-MI) is the most toxic. Serious toxic symptoms, a lack of counteracting drugs, and …
(CTX-MI) is the most toxic. Serious toxic symptoms, a lack of counteracting drugs, and …
A perspective on toxicology of Conus venom peptides
The evolutionarily unique and ecologically diverse family Conidae presents fundamental
opportunities for marine pharmacology research and drug discovery. The focus of this …
opportunities for marine pharmacology research and drug discovery. The focus of this …
Peptidomics in drug research
E Clynen, G Baggerman, SJ Husson… - Expert Opinion on …, 2008 - Taylor & Francis
Background: Because of their wide range of functions, endogenous peptides have great
potential either as drugs themselves or as drug targets. Objective: To provide an overview of …
potential either as drugs themselves or as drug targets. Objective: To provide an overview of …
Characterization of contryphans from Conus loroisii and Conus amadis that target calcium channels
Distinctly different effects of two closely related contryphans have been demonstrated on
voltage-activated Ca2+ channels. The peptides Lo959 and Am975 were isolated from …
voltage-activated Ca2+ channels. The peptides Lo959 and Am975 were isolated from …
Disulfide bond assignments by mass spectrometry of native natural peptides: cysteine pairing in disulfide bonded conotoxins
The critical, and often most difficult, step in structure elucidation of diverse classes of natural
peptides is the determination of correct disulfide pairing between multiple cysteine residues …
peptides is the determination of correct disulfide pairing between multiple cysteine residues …
Rapid mass spectral identification of contryphans. Detection of characteristic peptide ions by fragmentation of intact disulfide‐bonded peptides in crude venom
SS Thakur, P Balaram - … An International Journal Devoted to the …, 2007 - Wiley Online Library
The mass spectrometric cleavage of intact disulfide‐bonded peptides in conus venom has
been investigated. Contryphans containing a single disulfide bond are shown to fragment …
been investigated. Contryphans containing a single disulfide bond are shown to fragment …
Novel M‐Superfamily and T‐Superfamily conotoxins and contryphans from the vermivorous snail Conus figulinus
RP Rajesh - Journal of Peptide Science, 2015 - Wiley Online Library
The venom of Conus figulinus, a vermivorous cone snail, found in the south east coast of
India, has been studied in an effort to identify novel peptide toxins. The amino acid …
India, has been studied in an effort to identify novel peptide toxins. The amino acid …
Contryphan genes and mature peptides in the venom of nine cone snail species by transcriptomic and mass spectrometric analysis
M Vijayasarathy, SM Basheer, JB Franklin… - Journal of Proteome …, 2017 - ACS Publications
The occurrence of contryphans, a class of single-disulfide-bond-containing peptides, is
demonstrated by the analysis of the venom of nine species of cone snails. Ten full gene …
demonstrated by the analysis of the venom of nine species of cone snails. Ten full gene …
Sequencing of T-superfamily conotoxins from Conus virgo: Pyroglutamic acid identification and disulfide arrangement by MALDI mass spectrometry
De novo mass spectrometric sequencing of two Conus peptides, Vi1359 and Vi1361, from
the vermivorous cone snail Conus virgo, found off the southern Indian coast, is presented …
the vermivorous cone snail Conus virgo, found off the southern Indian coast, is presented …