Background Morphological changes of the lumbar spine muscles are not well characterised
with ageing. To further the understanding of age-related degeneration of the lumbar spine …

Background TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates
the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 …

Aim The aim of this study was to evaluate age-related changes in lumbar paravertebral
muscle (LPM) morphology in healthy younger and older adult men. Methods T2-weighted …

Recent years have seen steady progress in the identification of genetic muscle diseases as
well as efforts to develop treatment for these diseases. Consequently, sensitive and …

Background and objective TK2 deficiency (TK2d) is a rare mitochondrial disorder that
manifests predominantly as a progressive myopathy with a broad spectrum of severity and …

Background: Late-onset multiple acyl-coA dehydrogenase deficiency (MADD) is an
autosomal recessive inherited metabolic disorder. It is still unclear about the muscle …

Background and Objectives Glycogen storage disease type V (GSDV) or McArdle disease is
a muscle glycogenosis that classically manifests with exercise intolerance and exercise …

Abstract Introduction/Aims Ryanodine receptor 1 (RYR1)‐related myopathies associated
with variants in the RYR1 gene present with a wide range of symptoms and severity. Two of …

Background The primary disease mechanism underlying mitochondrial myopathies (MM) is
impaired energy generation to support muscle endurance. Little is known about muscle …

Age-related differences in muscle morphology, strength and biomechanical function of the
lumbar spine in healthy younger versus Page 1 Coventry University DOCTOR OF PHILOSOPHY …