The ubiquitin proteasome system maintains protein homeostasis by regulating the
breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The …

Cellular homeostasis is constantly challenged by a myriad of extrinsic and intrinsic stressors.
To mitigate the stress-induced damage, cells activate transient survival programs. The heat …

Protein-and RNA-containing foci and aggregates are a hallmark of many age-and mutation-
related neurodegenerative diseases. This article focuses on the role the nucleolus has as a …

Abnormal epigenetic regulation is identified to correlate with cancer progression and
renders tumor refractory and resistant to reactive oxygen species (ROS)‐based anti‐tumor …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Neddylation is the post-translational protein modification most closely related to
ubiquitination. Whereas the ubiquitin-like protein NEDD8 is well studied for its role in …

Post-translational modifications (PTMs) by ubiquitin (Ub) are versatile, highly dynamic, and
involved in nearly all aspects of eukaryote biological function. The reversibility and …

All cells contain specialized signaling pathways that enable adaptation to specific molecular
stressors. Yet, whether these pathways are centrally regulated in complex physiological …

Natural-derived peptides are effective substances in attenuating oxidative stress. However,
their specific mechanisms have not been fully elucidated, especially in peptide-mediated …

Protein ubiquitylation is a post-translational modification (PTM) process that covalently
modifies a protein substrate with either mono-ubiquitin moieties or poly-ubiquitin chains …