The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

The liver is an organ that performs a multitude of functions, and its health is pertinent and
indispensable to survival. Thus, the cellular and molecular machinery driving hepatic …

Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

Liver cancer is among the leading global healthcare issues associated with high morbidity
and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma …

With the rapid expansion of the obesity epidemic, nonalcoholic fatty liver disease is now the
most common chronic liver disease, with almost 25% global prevalence. Nonalcoholic fatty …

Chronic diseases account for approximately 45% of all deaths in developed countries and
are particularly prevalent in countries with the most sophisticated and robust public health …

Cardiovascular disease (CVD) and cancer are leading causes of mortality and morbidity
worldwide. Strategies to improve their treatment and prevention are global priorities and …

AXIN2 and LGR5 mark intestinal stem cells (ISCs) that require WNT/β-Catenin signaling for
constant homeostatic proliferation. In contrast, AXIN2/LGR5+ pericentral hepatocytes show …

Metabolic syndrome (MetS) is a cluster ofassociated metabolic traits that collectively confer
unsurpassed risk for development of cardiovascular disease (CVD) and type 2 diabetes …

The liver has a critical role in regulating host metabolism, immunity, detoxification, and
homeostasis. Proper liver function is essential for host health, and dysregulation of hepatic …