Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

The cytokines of the interleukin 17 (IL-17) family play a central role in the control of
infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory …

The development of atopic dermatitis (AD) in infancy and subsequent allergic rhinitis and
asthma in later childhood is known as the atopic march. This progressive atopy is dependent …

Filaggrin Mutations Associated with Skin and Allergic Diseases | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that
often precedes asthma and allergic disorders. New insights into the genetics and …

The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the
cause of ichthyosis vulgaris—the most common disorder of keratinization—and also a strong …

The skin is a complex and dynamic ecosystem that is inhabited by many microorganisms.
Recent evidence highlights the profound reliance of the skin immune system on its resident …

Atopic dermatitis (AD) is a chronic inflammatory skin disease that is often associated with the
development of food allergy and asthma. New insights into AD reveals an important role for …

The quality of physician–patient interaction is increasingly being recognized as an essential
component of effective treatment. The present article reports on the development and …