Herpesviruses are ubiquitous, double-stranded DNA, enveloped viruses that establish
lifelong infections and cause a range of diseases. Entry into host cells requires binding of …

Herpes simplex virus (HSV) can infect a broad host range and cause mild to life threating
infections in humans. The surface glycoproteins of HSV are evolutionarily conserved and …

Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised
individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion …

Enveloped viruses employ a class of proteins known as fusogens to orchestrate the merger
of their surrounding envelope and a target cell membrane. Most fusogens accomplish this …

Herpesviral pathogenesis stems from infection of multiple cell types including the site of
latency and cells that support lytic replication. Herpesviruses utilize distinct cellular …

Many viruses are enveloped by a lipid bilayer acquired during assembly, which is typically
studded with one or two types of glycoproteins. These viral surface proteins act as the …

The biological and functional significance of selected Critical Assessment of Techniques for
Protein Structure Prediction 14 (CASP14) targets are described by the authors of the …

Relatively little is known about the extent of the polyclonal antibody (PAb) repertoire elicited
by herpes simplex virus (HSV) glycoproteins during natural infection and how these …

Members of the Herpesviridae, including the medically important alphaherpesvirus varicella-
zoster virus (VZV), induce fusion of the virion envelope with cell membranes during entry …

Neutralizing antibodies (NAbs) are naturally produced by our immune system to combat viral
infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have …