Dysregulation of TCTP in biological processes and diseases

UA Bommer, A Telerman - Cells, 2020 - mdpi.com
Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF)
or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is …

The translational controlled tumour protein TCTP: biological functions and regulation

UA Bommer - TCTP/tpt1-Remodeling Signaling from Stem Cell to …, 2017 - Springer
Abstract The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called
P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein …

Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer

F Zhang, Q Ma, Z Xu, H Liang, H Li, Y Ye… - Journal of Experimental …, 2017 - Springer
Background Patients with metastatic or relapsed gallbladder cancer generally have a poor
prognosis. Therefore, targeting metastasis is one arm of therapeutic strategies to treat …

A potential role for exosomal translationally controlled tumor protein export in vascular remodeling in pulmonary arterial hypertension

E Ferrer, BJ Dunmore, D Hassan… - American journal of …, 2018 - atsjournals.org
Pulmonary arterial hypertension (PAH) is characterized by increased proliferation and
resistance to apoptosis of pulmonary vascular cells. Increased expression of translationally …

Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU …

UA Bommer, KL Vine, P Puri, M Engel… - Cell Communication and …, 2017 - Springer
Background Translationally controlled tumour protein TCTP is an anti-apoptotic protein
frequently overexpressed in cancers, where high levels are often associated with poor …

miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42

P Sharma, N Saini, R Sharma - Oncology reports, 2017 - spandidos-publications.com
Previously, we reported significantly decreased expression of tissue and circulating miR-107
in esophageal cancer (EC). However, its role in esophageal tumorigenesis still remains …

Silencing Trim59 inhibits invasion/migration and epithelial-to-mesenchymal transition via TGF-β/Smad2/3 signaling pathway in bladder cancer cells

W Chen, K Zhao, C Miao, A Xu, J Zhang… - OncoTargets and …, 2017 - Taylor & Francis
The evolutionarily conserved genes that encode the tripartite motif (TRIM) protein family are
involved in various biological processes, including cellular immunity, inflammatory reaction …

Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects

J Gao, Y Ma, G Yang, G Li - Journal of Zhejiang University-SCIENCE B, 2022 - Springer
Translationally controlled tumor protein (TCTP) is a highly conserved multifunctional protein
localized in the cytoplasm and nucleus of eukaryotic cells. It is secreted through exosomes …

[HTML][HTML] Long noncoding RNA TPT1-AS1 promotes the progression and metastasis of colorectal cancer by upregulating the TPT1-mediated FAK and JAK-STAT3 …

L Zhang, F Ye, Z Zuo, D Cao, Y Peng, Z Li… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Tumour protein translationally controlled 1 (TPT1) antisense RNA 1 (TPT1-AS1) is known to
be involved in the development and metastasis of cervical and ovarian cancers; however, its …

[HTML][HTML] Harnessing the value of TCTP in breast cancer treatment resistance: an opportunity for personalized therapy

G Santamaria, M Cioce, A Rizzuto, VM Fazio… - Cancer Drug …, 2023 - ncbi.nlm.nih.gov
Early identification of breast cancer (BC) patients at a high risk of progression may aid in
therapeutic and prognostic aims. This is especially true for metastatic disease, which is …