Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints
such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No …

Mechanical factors play critical roles in the pathogenesis of joint disorders like osteoarthritis
(OA), a prevalent progressive degenerative joint disease that causes debilitating pain …

Objectives Basic calcium phosphate (BCP) crystal and interleukin 6 (IL-6) have been
implicated in osteoarthritis (OA). We hypothesise that these two factors may be linked in a …

Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and
possess a highly differentiated phenotype that is the hallmark of the unique physiological …

Excessive mechanical strain is the prominent risk factor for osteoarthritis (OA), causing
cartilage destruction and degeneration. However, the underlying molecular mechanism …

Extraosseous calcification is a pathologic mineralization process occurring in soft connective
tissues (eg, skin, vessels, tendons, and cartilage). It can take place on a genetic basis or as …

Osteoarthritis (OA) is a highly prevalent joint disease that causes substantial disability, yet
effective approaches to disease prevention or to the delay of OA progression are lacking …

Background: Calcium pyrophosphate (CPP) microcrystal deposition is associated with wide
clinical phenotypes, including acute and chronic arthritis, that are interleukin 1β (IL-1β) …