Tuberculosis (TB) remains one of the deadliest infectious diseases in human history,
prevailing even in the 21st century. The causative agents of TB are represented by a group …

Mycobacterium tuberculosis (Mtb) replicates within host macrophages by adapting to the
stressful and nutritionally constrained environments in these cells. Exploiting these …

Cyclic AMP (cAMP) is a ubiquitous second messenger that transduces signals from cellular
receptors to downstream effectors. Mycobacterium tuberculosis (Mtb), the etiological agent …

Background Bacterial diversity could contribute to the diversity of tuberculosis infection and
treatment outcomes observed clinically, but the biological basis of this association is poorly …

Cyclic AMP (cAMP) signaling is essential to Mycobacterium tuberculosis (Mtb)
pathogenesis. However, the roles of phosphodiesterases (PDEs) Rv0805, and the recently …

How has metabolomics helped our understanding of infectious diseases? With the threat of
antimicrobial resistance to human health around the world, metabolomics has emerged as a …

Nucleotide signalling molecules–mainly cyclic 3′, 5′-adenosine phosphate (cAMP), bis-
(3′, 5′)-cyclic diguanosine monophosphate (c-di-GMP), and bis-(3′, 5′)-cyclic …

Survival of Mycobacterium tuberculosis within the host macrophages requires the bacterial
virulence regulator PhoP, but the underlying reason remains unknown. 3′, 5′-Cyclic …

Mycobacterial genomes encode multiple adenylyl cyclases and cAMP effector proteins,
underscoring the diverse ways these bacteria utilize cAMP. We identified universal stress …

Background Combatting the tuberculosis (TB) epidemic caused by Mycobacterium
tuberculosis (Mtb) necessitates a better understanding of the factors contributing to patient …