Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

A role for somatic mutations in carcinogenesis is well accepted, but the degree to which
mutation rates influence cancer initiation and development is under continuous debate …

Somatic mutations in driver genes may ultimately lead to the development of cancer.
Understanding how somatic mutations accumulate in cancer genomes and the underlying …

Cancer genome sequencing has revealed considerable variation in somatic mutation rates
across the human genome, with mutation rates elevated in heterochromatic late replicating …

Somatic mutations are an inevitable component of ageing and the most important cause of
cancer. The rates and types of somatic mutation vary across individuals, but relatively few …

Practical and clinically focused, Abeloff's Clinical Oncology is a trusted medical reference
book designed to capture the latest scientific discoveries and their implications for cancer …

Inactivation of one X chromosome in mammalian females achieves dosage compensation
between XX females and XY males; however, over 15% of human X-linked genes continue …

Chromosomal rearrangements are generally thought to accumulate gradually over many
generations. However, DNA sequencing of cancer and congenital disorders uncovered a …

In cancer, much uncertainty remains regarding the origins of metastatic disease. Models of
metastatic progression offer competing views on when dissemination occurs (at an early or …

Human pluripotent stem cells (hPSCs) are being increasingly utilized worldwide in
investigating human development, and modeling and discovering therapies for a wide range …