Over the past two decades a growing body of evidence has demonstrated an important role
of tight junction (TJ) proteins in the physiology and disease biology of GI and liver disease …

Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis
and hepatocellular carcinoma. It imposes a serious problem to public health in the world as …

Hepatitis C virus, a major human pathogen, produces infectious virus particles with several
unique features, such as an ability to interact with serum lipoproteins, a dizzyingly …

Apoptosis is a prominent feature of liver diseases. Causative factors such as alcohol,
viruses, toxic bile acids, fatty acids, drugs, and immune response, can induce apoptotic cell …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

ABSTRACT A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key
factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is …

Interferon-gamma (IFNG) is a pleiotropic cytokine that modulates both innate and adaptive
immune networks; it is the most potent activator of macrophages and a signature cytokine of …

Viruses initiate infection by attaching to molecules or receptors at the cell surface. Hepatitis
C virus (HCV) enters cells via a multistep process involving tetraspanin CD81, scavenger …

Hepatitis C virus (HCV) is a hepatotropic virus and a major cause of chronic hepatitis and
liver disease worldwide. Initial interactions between HCV virions and hepatocytes are …

Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma.
Preventive modalities are absent and the current antiviral treatment is limited by resistance …