The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Solute carrier (SLC) transporters—a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes—have …

Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …

This white paper provides updated International Transporter Consortium (ITC)
recommendations on transporters that are important in drug development following the 3rd …

In recent decades, in silico absorption, distribution, metabolism, excretion (ADME), and
toxicity (T) modelling as a tool for rational drug design has received considerable attention …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The most widespread type of liver cancer, HCC, is associated with disabled cellular death
pathways. Despite therapeutic advancements, resistance to current systemic treatments …

The International Transporter Consortium (ITC) has recently described seven transporters of
particular relevance to drug development. Based on the second ITC transporter workshop in …

Motivation The absorption, distribution, metabolism, excretion, and toxicity (ADMET) of drugs
plays a key role in determining which among the potential candidates are to be prioritized. In …

Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …