The paraganglioma (PGL) syndromes types 1–5 are autosomal dominant disorders
characterized by familial predisposition to PGLs, phaeochromocytomas (PCs), renal cell …

ABSTRACT Never in Mitosis (NIMA) Related Kinase 2 (NEK2) plays a key role in regulating
mitotic processes, including centrosome duplication and separation, microtubule …

Mammalian Aurora family of serine/threonine kinases are master regulators of mitotic
progression and are frequently overexpressed in human cancers. Among the three …

TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …

Accumulating evidence suggests that glioma stem cells (GSCs) are important therapeutic
targets in glioblastoma (GBM). In this study, we identified NIMA-related kinase 2 (NEK2) as a …

This study aims to identify promising biomarkers for the early detection of lung cancer and
evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data …

Cancer is characterized by uncontrolled cell proliferation due to the aberrant activity of
various proteins. Cell cycle-related proteins are thought to be important in several functions …

Never in mitosis gene-A (NIMA)-related expressed kinase 2 (NEK2) has been recently
reported to play a role in tumor progression, drug resistance and tumorigenesis. However …

Abstract Nek2 (NIMA‐related kinase 2) is a serine/threonine-protein kinase that localizes to
centrosomes and kinetochores, controlling centrosome separation, chromosome …

The serine/threonine kinase Nek2 (NIMA‐related kinase 2) regulates centrosome separation
and mitotic progression, with overexpression causing induction of aneuploidy in vitro …