Optical tweezers have become the method of choice in single-molecule manipulation
studies. In this Primer, we first review the physical principles of optical tweezers and the …

Soft matter exhibits a multitude of intrinsic physico-chemical attributes. Their mechanical
properties are crucial characteristics to define their performance. In this context, the rigidity of …

Trophic interactions play a vital role in soil functioning and are increasingly considered as
important drivers of the soil microbiome and biogeochemical cycles. In the last decade …

Over the last 60 years, soil microbiologists have accumulated a wealth of experimental data
showing that the bulk, macroscopic parameters (eg, granulometry, pH, soil organic matter …

Since their invention in 1986 by Arthur Ashkin and colleagues, optical tweezers have
become an essential tool in several fields of physics, spectroscopy, biology …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …

Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II)
must overcome during transcription. A high-resolution description of the barrier topography …

Single-molecule force spectroscopy is a unique method that can probe the structural
changes of single proteins at a high spatiotemporal resolution while mechanically …

摘要光镊采用聚焦的激光束束缚微米, 纳米级的粒子, 具有亚皮牛级的力分辨率和亚毫秒级的
时间响应, 在单分子生物物理中具有广泛的应用. 通过化学耦链将生物大分子连接到高分子微球 …

Telomere maintenance by telomerase is essential for continuous proliferation of human cells
and is vital for the survival of stem cells and 90% of cancer cells. To compensate for …