Targeting fatty acid metabolism in glioblastoma

J Miska, NS Chandel - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and
resistance to conventional therapies. There have been considerable efforts to untangle the …

Structure, biochemical function, and signaling mechanism of plant NLRs

J Wang, W Song, J Chai - Molecular Plant, 2023 - cell.com
To counter pathogen invasion, plants have evolved a large number of immune receptors,
including membrane-resident pattern recognition receptors (PRRs) and intracellular …

TIR domains of plant immune receptors are 2′, 3′-cAMP/cGMP synthetases mediating cell death

D Yu, W Song, EYJ Tan, L Liu, Y Cao, J Jirschitzka, E Li… - Cell, 2022 - cell.com
Summary 2′, 3′-cAMP is a positional isomer of the well-established second messenger
3′, 5′-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide …

Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products

AM Bayless, S Chen, SC Ogden, X Xu, JD Sidda… - Science …, 2023 - science.org
Toll/interleukin-1 receptor (TIR) domain proteins function in cell death and immunity. In
plants and bacteria, TIR domains are often enzymes that produce isomers of cyclic …

Stress-related biomolecular condensates in plants

J Solis-Miranda, M Chodasiewicz, A Skirycz… - The Plant …, 2023 - academic.oup.com
Biomolecular condensates are membraneless organelle-like structures that can concentrate
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …

Plant stress granules: trends and beyond

I Maruri-López, NE Figueroa… - Frontiers in Plant …, 2021 - frontiersin.org
Stress granules (SGs) are dynamic membrane-less condensates transiently assembled
through liquid–liquid phase separation (LLPS) in response to stress. SGs display a biphasic …

Composition and function of stress granules and P-bodies in plants

A Kearly, ADL Nelson, A Skirycz… - Seminars in cell & …, 2024 - Elsevier
Abstract Stress Granules (SGs) and Processing-bodies (P-bodies) are biomolecular
condensates formed in the cell with the highly conserved purpose of maintaining balance …

Arabidopsis metacaspase MC1 localizes in stress granules, clears protein aggregates, and delays senescence

N Ruiz-Solaní, J Salguero-Linares, L Armengot… - The Plant …, 2023 - academic.oup.com
Stress granules (SGs) are highly conserved cytoplasmic condensates that assemble in
response to stress and contribute to maintaining protein homeostasis. These membraneless …

[HTML][HTML] TIR-domain enzymatic activities at the heart of plant immunity

F Locci, J Wang, JE Parker - Current Opinion in Plant Biology, 2023 - Elsevier
Abstract Toll/interleukin-1/resistance (TIR) domain proteins contribute to innate immunity in
all cellular kingdoms. TIR modules are activated by self-association and in plants, mammals …

Tudor staphylococcal nuclease is a docking platform for stress granule components and is essential for SnRK1 activation in Arabidopsis

E Gutierrez‐Beltran, PH Elander, K Dalman… - The EMBO …, 2021 - embopress.org
Tudor staphylococcal nuclease (TSN; also known as Tudor‐SN, p100, or SND1) is a
multifunctional, evolutionarily conserved regulator of gene expression, exhibiting …