The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

ABC (ATP binding cassette) transporters, ubiquitous in all kingdoms of life, carry out
essential substrate transport reactions across cell membranes. Their transmembrane …

Drug export from cells is a major factor in the acquisition of cellular resistance to
antimicrobial and cancer chemotherapy, and poses a significant threat to future clinical …

P-Glycoprotein (P-gp) is a transmembrane protein belonging to the ATP binding cassette
superfamily of transporters, and it is a xenobiotic efflux pump that limits intracellular drug …

Multicomponent transporters are used by bacteria to transport a wide range of nutrients.
These systems use a substrate-binding protein to bind the nutrient with high affinity and then …

Molecular dynamics (MD) simulations have been used extensively to study P-glycoprotein
(P-gp), a flexible multidrug transporter that is a key player in the development of multidrug …

Multidrug resistance (MDR) caused by overexpressed permeability–glycoprotein (P-gp) in
cancer cells is the main barrier for the cure of cancers. P-gp can pump many …

Efflux pumps of the ATP-binding cassette transporters superfamily (ABC transporters) are
frequently involved in the multidrug-resistance (MDR) phenomenon in cancer cells. Herein …

Leishmaniasis is a neglected tropical disease infecting the world's poorest populations.
Miltefosine (ML) remains the primary oral drug against the cutaneous form of leishmaniasis …

Over the past decade, molecular dynamics (MD) simulations have become particularly
powerful to rationalize drug insertion and partitioning in lipid bilayers. MD simulations …