Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Background: Depression is the most debilitating neuropsychiatric disorder with significant
impact on socio-occupational and well being of individual. The exact pathophysiology of …

The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …

In the developing and mature brain, mitochondria act as central hubs for distinct but
interwined pathways, necessary for neural development, survival, activity, connectivity and …

Background Curcumin has been demonstrated to have many neuroprotective properties,
including improvement of cognition in humans and neurogenesis in animals, yet the …

Mitochondria maintain the normal physiological function of nerve cells by producing
sufficient cellular energy and performing crucial roles in maintaining the metabolic balance …

Mitochondria are the prime source of cellular energy, and are also responsible for important
processes such as oxidative stress, apoptosis and Ca2+ homeostasis. Depression is a …

Growing evidence suggests that inflammatory processes may be involved in depressive
disorders. Inflammation is known to induce mitochondrial dysfunction in the nervous system …

Adult neurogenesis defects have been demonstrated in the brains of Alzheimer's disease
(AD) patients. The neurogenesis impairment is an early critical event in the course of familiar …