Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms
Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …
Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective
K Hashimoto - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Major depressive disorder (MDD) is one of the most disabling psychiatric disorders.
Approximately one‐third of the patients with MDD are treatment resistant to the current …
Approximately one‐third of the patients with MDD are treatment resistant to the current …
Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor
We show that the sex of human experimenters affects mouse behaviors and responses
following administration of the rapid-acting antidepressant ketamine and its bioactive …
following administration of the rapid-acting antidepressant ketamine and its bioactive …
Attenuation of antidepressant effects of ketamine by opioid receptor antagonism
Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces
opioid system activation. The objective of this study was to determine whether opioid …
opioid system activation. The objective of this study was to determine whether opioid …
Psychedelics and neural plasticity: therapeutic implications
Psychedelic drugs have reemerged as tools to treat several brain disorders. Cultural
attitudes toward them are changing, and scientists are once again investigating the neural …
attitudes toward them are changing, and scientists are once again investigating the neural …
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
The discovery of the antidepressant effects of ketamine has opened a breakthrough
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
Ketamine and serotonergic psychedelics: an update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment
The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …
understand its underlying mechanisms of action and to identify other novel compounds that …
Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function
EW Lumsden, TA Troppoli, SJ Myers… - Proceedings of the …, 2019 - National Acad Sciences
Preclinical studies indicate that (2 R, 6 R)-hydroxynorketamine (HNK) is a putative fast-
acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors …
acting antidepressant candidate. Although inhibition of NMDA-type glutamate receptors …
Convergent mechanisms underlying rapid antidepressant action
Traditional pharmacological treatments for depression have a delayed therapeutic onset,
ranging from several weeks to months, and there is a high percentage of individuals who …
ranging from several weeks to months, and there is a high percentage of individuals who …
Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals
Ketamine improves motivation-related symptoms in depression but simultaneously elicits
similar symptoms in healthy individuals, suggesting that it might have different effects in …
similar symptoms in healthy individuals, suggesting that it might have different effects in …