Intervertebral disc degeneration (IVDD) is a frequent and intractable chronic condition in
orthopedics that causes enormous discomfort in patients' lives and thoughts, as well as a …

Intervertebral disc degeneration (IVDD) is a main cause of low back pain (LBP), which can
lead to disability and thus generate a heavy burden on society. IVDD is characterized by a …

Background Intervertebral disc degeneration (IVDD) is the primary etiology of low back pain
and radicular pain. Recent studies have found that chemokines play a role in IVDD, but the …

Intervertebral disc degeneration (IDD) has been widely recognized as the primary cause of
low back pain and is one of the major chronic diseases imposing a severe socioeconomic …

Lower back pain (LBP), which is a primary cause of disability, is largely attributed to
intervertebral disc degeneration (IDD). Macrophages (MΦs) in degenerated intervertebral …

Currently, mitochondrial dysfunction caused by oxidative stress is a growing concern in
degenerative diseases, notably intervertebral disc degeneration (IVDD). Dysregulation of …

Intervertebral disc degeneration is a degenerative disease where inflammation and immune
responses play significant roles. Macrophages, as key immune cells, critically regulate …

Background The role of basal metabolic rate (BMR) in intervertebral disc degeneration
(IVDD) is still uncertain. To address this gap, we conducted a Mendelian randomization …

Intervertebral disc degeneration (IDD)-induced lower back pain (LBP) brings heavy burden
worldwide. In the degenerated intervertebral disc, there is an increase in the accumulation of …

The circadian clock orchestrates a broad spectrum of physiological processes, crucially
modulating human biology across an approximate 24-hour cycle. The circadian …