The signal recognition particle (SRP) and its receptor compose a universally conserved and
essential cellular machinery that couples the synthesis of nascent proteins to their proper …

Pioneering electron microscopy studies defined two primary populations of ribosomes in
eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the …

Imaging biological processes in mammalian tissues will be facilitated by fluorescent probes
with excitation and emission bands within the near-infrared optical window of high …

The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the
protein translocon, which facilitates membrane integration or translocation of almost every …

The heterotrimeric Sec61 complex and the dimeric Sec62/Sec63 complex are located in the
membrane of the human endoplasmic reticulum (ER) and play a central role in translocation …

Protein translocation into the endoplasmic reticulum (ER) is the first and decisive step in the
biogenesis of most extracellular and many soluble organelle proteins in eukaryotic cells. It is …

The evolution of eukaryotes was accompanied by an increased need for intracellular
communication and cellular specialization. Thus, a more complex collection of secreted and …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Amino-terminal acetylation is probably the most common protein modification in eukaryotes
with as many as 50%–80% of proteins reportedly altered in this way. Here we report a …

Co-translational transport of polypeptides into the endoplasmic reticulum (ER) involves the
Sec61 channel and additional components such as the ER lumenal Hsp70 BiP and its …