Lipid droplets (LDs), initially considered “inert” lipid deposits, have gained during the last
decade the classification of cytosolic organelles due to their defined composition and the …

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling
organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most …

As essential regulators of mitochondrial quality control, mitochondrial dynamics and
mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here …

In mammalian skin, multiple types of resident cells are required to create a functional tissue
and support tissue homeostasis and regeneration. The cells that compose the epithelial …

Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells
induce oxidative stress in adjacent cancer-associated fibroblasts, resulting in the …

Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic
exposure to cigarette smoke (CS), which involves airway obstruction and alveolar loss (ie …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Objective: Endothelial Cav-1 (caveolin-1) expression plays a relevant role during
atherogenesis by controlling NO production, vascular inflammation, LDL (low-density …

Excess or insufficient lipid storage in white adipose tissue lipid droplets is associated with
dyslipidemia, insulin resistance and increased risk for diabetes type 2. Thus, maintenance of …

CAV1 (caveolin 1, caveolae protein, 22kDa) is well known as a principal scaffolding protein
of caveolae, a specialized plasma membrane structure. Relatively, the caveolae …