The TAM receptor tyrosine kinases (RTKs)—T YRO3, A XL, and M ERTK—together with their
cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation …

This review is an account of how pulmonary damage caused by cigarette smoke and other
environmental toxins can incite inflammatory and immunologic reactions that culminate in …

To maintain organismal homeostasis, phagocytes engulf dead cells, which are recognized
as dead by virtue of a characteristic" eat me" signal exposed on their surface. The dead cells …

Recent studies have revealed that the TAM receptor protein tyrosine kinases—TYRO3, AXL
and MER—have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells …

In germinal centres, somatic hypermutation and B cell selection increase antibody affinity
and specificity for the immunizing antigen, but the generation of autoreactive B cells is an …

Increasing age alters innate immune–mediated responses; however, the mechanisms
underpinning these changes in humans are not fully understood. Using a human dermal …

Apoptosis happens continuously for millions of cells along with the active removal of
apoptotic debris in order to maintain tissue homeostasis. In this respect, efferocytosis, ie, the …

Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease.
Impaired clearance functions for dying cells may explain accumulation of nuclear …

Follicular dendritic cells (FDCs) were originally identified by their specific morphology and
by their ability to trap immune-complexed antigen in B cell follicles. By virtue of the latter as …

The TAM receptor tyrosine kinases Tyro3, Axl, and Mer and their ligands Gas6 and Protein S
are essential for the phagocytosis of apoptotic cells and membranes in the adult immune …