An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

Endothelial cells line all blood vessels and are critical regulators of vascular tone. In
hypertension, disruption of endothelial function alters the release of endothelial-derived …

Diabetic endothelial dysfunction associated with diminished endothelial nitric oxide (NO)
synthase (eNOS) activity accelerates the development of atherosclerosis and …

A monolayer of endothelial cells lines the innermost surface of all blood vessels, thereby
coming into close contact with every region of the body and perceiving signals deriving from …

The contractile state of resistance arteries and arterioles is a crucial determinant of blood
pressure and blood flow. Physiological regulation of arterial contractility requires constant …

Background Vascular smooth muscle cell (VSMC) proliferation is involved in many types of
arterial diseases, including neointima hyperplasia, in which Ca2+ has been recognized as a …

Cardiovascular diseases are closely related to hypertension, type 2 diabetes mellitus,
obesity, and hyperlipidemia. Many studies have reported that an unhealthy diet and …

Calcium signaling is essential for regulating many biological processes. Endoplasmic
reticulum inositol trisphosphate receptors (IP 3 Rs) and the mitochondrial Ca 2+ uniporter …

The epsin family of endocytic adapter proteins are widely expressed, and interact with both
proteins and lipids to regulate a variety of cell functions. However, the role of epsins in …